Point Spread: -1.50 | -111.00 New England (Home)
The spot, matchup and injury situation strongly favor the Patriots, who have covered 67 percent of the time during the past 74 instances following a loss.
The Patriots were in a tough spot last week unable to practice on the field because their facilities were shut down due to COVID. It's business as usual this week for the Patriots, who have been able to practice and get back to their normal routine.
It's the 49ers who have the bad timing. They just defeated the Rams at home in a pivotal division game this past Sunday. San Francisco has another huge division game next week against the Seahawks.
Cam Newton should finally be back to 100 percent. The Patriots are expected to get reinforcements back on both their offensive and defensive lines, including star center David Andrews.
The 49ers aren't as lucky. They are down their best running back and have multiple defensive injuries to a number of important players, including Nick Bosa, Richard Sherman, Dee Ford, Kwon Alexander and Solomon Thomas.
Jimmy Garoppolo hasn't played well this season. Garoppolo backed up Tom Brady before going to the 49ers. Belichick certainly knows Garoppolo's tendencies.
Both teams are ground-oriented and conservative. Newton is superior to Garoppolo. The Patriots also have the stronger secondary and Belichick is the best coach in football.